Clarke C S, Otridge B W, Carney D N
Department of Haematology, Mater Misericordiae Hospital, Dublin, Ireland.
Cancer. 1990 Nov 1;66(9):2027-30. doi: 10.1002/1097-0142(19901101)66:9<2027::aid-cncr2820660930>3.0.co;2-u.
In a retrospective survey of 85 patients who received chemotherapy as treatment for non-Hodgkin's lymphomas, the authors found that clinically apparent thromboembolic disorders occurred in four of 11 patients receiving weekly chemotherapy, and in none of 74 patients who were treated on less intensive schedules, suggesting that intensive weekly chemotherapy is thrombogenic. The possible mechanisms of this effect are discussed.
在一项针对85例接受化疗以治疗非霍奇金淋巴瘤患者的回顾性调查中，作者发现，在11例接受每周一次化疗的患者中有4例出现了临床明显的血栓栓塞性疾病，而在74例接受强度较低化疗方案治疗的患者中无一例出现，这表明每周进行强化化疗具有致血栓形成作用。文中讨论了这种效应可能的机制。
