链球菌 IdeS 及其对免疫应答和炎症的影响。
Streptococcal IdeS and its impact on immune response and inflammation.
机构信息
Department of Molecular Biology and Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.
出版信息
J Innate Immun. 2012;4(2):132-40. doi: 10.1159/000332940. Epub 2012 Jan 17.
Abstract
Survival of the important bacterial pathogen Streptococcus pyogenes relies on its ability to circumvent the antimicrobial actions of innate and specific immune responses and to modulate the inflammatory responses induced during the course of an infection. Inflammatory processes play key roles during streptococcal pathogenesis and streptococcal infections are accompanied by an intense inflammatory state. As an exclusively human pathogen, S. pyogenes has adapted to the various countermeasures employed by its host to fight bacterial infections, in particular to interfere with the effector functions of immunoglobulin G (IgG). For this purpose, S. pyogenes has evolved an IgG-specific endopeptidase, IdeS, which is highly specific for the lower hinge region of IgG. This review summarizes the current knowledge about this intriguing enzyme as well as its role in inflammation and in the attenuation of human immune responses towards streptococcal infection.
摘要
重要的细菌病原体化脓链球菌的生存依赖于其规避先天和特异性免疫反应的抗菌作用的能力，以及调节感染过程中诱导的炎症反应的能力。炎症过程在链球菌发病机制中起着关键作用，链球菌感染伴随着强烈的炎症状态。作为一种专门的人类病原体，化脓链球菌已经适应了宿主用来对抗细菌感染的各种对策，特别是干扰免疫球蛋白 G（IgG）的效应功能。为此，化脓链球菌进化出一种 IgG 特异性内肽酶 IdeS，它对 IgG 的下铰链区域具有高度特异性。这篇综述总结了关于这种有趣的酶的最新知识，以及它在炎症和减轻人类对链球菌感染的免疫反应中的作用。
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