抗体依赖性增强细菌病：流行情况、机制与治疗。
Antibody-Dependent Enhancement of Bacterial Disease: Prevalence, Mechanisms, and Treatment.
机构信息
The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Australia.
The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Australia
出版信息
Infect Immun. 2021 Mar 17;89(4). doi: 10.1128/IAI.00054-21.
Antibody-dependent enhancement (ADE) of viral disease has been demonstrated for infections caused by flaviviruses and influenza viruses; however, antibodies that enhance bacterial disease are relatively unknown. In recent years, a few studies have directly linked antibodies with exacerbation of bacterial disease. This ADE of bacterial disease has been observed in mouse models and human patients with bacterial infections. This antibody-mediated enhancement of bacterial infection is driven by various mechanisms that are disparate from those found in viral ADE. This review aims to highlight and discuss historic evidence, potential molecular mechanisms, and current therapies for ADE of bacterial infection. Based on specific case studies, we report how plasmapheresis has been successfully used in patients to ameliorate infection-related symptomatology associated with bacterial ADE. A greater understanding and appreciation of bacterial ADE of infection and disease could lead to better management of infections and inform current vaccine development efforts.
抗体依赖性增强（ADE）已在黄病毒和流感病毒引起的感染中得到证实；然而，增强细菌病的抗体则相对未知。近年来，一些研究直接将抗体与细菌病的恶化联系起来。这种细菌病的 ADE 已在携带细菌感染的小鼠模型和人类患者中观察到。这种抗体介导的细菌感染增强是由各种机制驱动的，这些机制与病毒 ADE 中的机制不同。本综述旨在强调和讨论细菌感染 ADE 的历史证据、潜在分子机制和当前疗法。基于具体的案例研究，我们报告了如何成功地使用血浆置换术来改善与细菌 ADE 相关的感染相关症状。对感染和疾病的细菌 ADE 的更深入理解和认识，可以改善感染的管理，并为当前的疫苗开发工作提供信息。
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