Department of Neurosurgery, Royal Brisbane and Women's Hospital, Butterfield Street, Herston, Queensland 4029, Australia.
J Clin Neurosci. 2012 Mar;19(3):477-8. doi: 10.1016/j.jocn.2011.06.019. Epub 2012 Jan 16.
Ollier disease is a rare disorder characterised by the development of multiple enchondromas in long bones. Here we present a 19-year-old man with Ollier disease who also developed three synchronous brain tumours. Craniotomy, biopsy and debulking was performed for one lesion followed by a period of observation, and 9 months later he underwent a second craniotomy and debulking for symptomatic progression. Histopathological examination revealed a diagnosis of multifocal diffuse glioma (World Health Organization grade II). This report highlights the increased incidence of primary brain tumours in patients with Ollier disease and identifies the importance of screening patients with Ollier disease for primary neoplasms.
奥利尔病是一种罕见的疾病，其特征是长骨中多个内生软骨瘤的发展。这里我们介绍了一位 19 岁的奥利尔病患者，他还同时患上了三个脑肿瘤。对一个病变进行了开颅手术、活检和去瘤手术，然后进行了一段时间的观察，9 个月后，他因症状进展进行了第二次开颅手术和去瘤手术。组织病理学检查显示多发性弥漫性神经胶质瘤的诊断（世界卫生组织二级）。本报告强调了奥利尔病患者原发性脑肿瘤发病率的增加，并确定了对奥利尔病患者进行原发性肿瘤筛查的重要性。
