Sato E, Tokunaga M, Hasui K, Kitajima S, Nomoto M
Department of Pathology, Faculty of Medicine, Kagoshima University, Japan.
Cancer Detect Prev. 1990;14(4):423-9.
In order to elucidate the pathological and epidemiological features of malignant lymphoma (ML), particularly of adult T-cell lymphoma/leukemia (ATLL) in the Kagoshima district, age-adjusted and age-specific incidence rates of malignant lymphomas were estimated on 3239 histologically confirmed cases between the years 1963 and 1987. There was a marked increase in the incidence rate from 1976 (4.9) to 1982 (8.5) due to the increase of T-cell lymphomas. The increase was not conspicuous after 1982. Immunohistochemically, all of the 429 MLs found in 1985 and 1986 were examined on paraffin sections and 70 ATLL cases on fresh frozen sections. T-cell ML comprised 65.3%, B-cell ML 30.5%, Hodgkin disease 2.6%, and histiocytic ML 1.2%. Most of ATLL cells were phenotypically CD4+ CD8-, 14% of ATLL cases showed CD4+ CD8+, 6% were CD4- CD8+, and 7% were CD4- CD8-. The simulataneous expression of IL 2 and IL 2R was seen in 8 (16%) out of 56 patients examined. Therefore, a proliferation by autocrine mechanism does not seem to be a major course of ATLL progression.
为阐明恶性淋巴瘤（ML），尤其是鹿儿岛地区成人T细胞淋巴瘤/白血病（ATLL）的病理和流行病学特征，我们根据1963年至1987年间3239例经组织学确诊的病例，估算了恶性淋巴瘤的年龄调整发病率和年龄别发病率。由于T细胞淋巴瘤的增加，发病率从1976年的4.9显著上升至1982年的8.5。1982年之后，这种上升并不明显。免疫组织化学方面，对1985年和1986年发现的429例ML石蜡切片以及70例ATLL新鲜冰冻切片进行了检查。T细胞ML占65.3%，B细胞ML占30.5%，霍奇金病占2.6%，组织细胞性ML占1.2%。大多数ATLL细胞表型为CD4 + CD8 -，14%的ATLL病例表现为CD4 + CD8 +，6%为CD4 - CD8 +，7%为CD4 - CD8 -。在所检查的56例患者中，8例（16%）出现白细胞介素2（IL 2）和白细胞介素2受体（IL 2R）的同时表达。因此，自分泌机制的增殖似乎并非ATLL进展的主要过程。
