Department of Psychiatry and Behavioral Sciences, Child and Adolescent Division, Emory University Hospital, 1256 Briarcliff Road Suite 309 East, Atlanta, GA, 30306, USA.
Eur Child Adolesc Psychiatry. 2012 Mar;21(3):165-8. doi: 10.1007/s00787-012-0239-z. Epub 2012 Jan 17.
It is widely known that discontinuation reactions can occur after neuroleptics are stopped resulting in dyskinesia through its effect on the nigrostriatal pathway. Less discussed is the concept of "supersensitivity psychosis" which has been described as a rapid onset of psychosis after a neuroleptic medication has been withdrawn. Although the concept of supersensitivity psychosis has been described with the discontinuation of some neuroleptics, it has not been described with ziprasidone. Furthermore, the following case report is the first time that this phenomenon has been described in an adolescent patient who has discontinued ziprasidone. Reasons for supersensitivity psychosis are explored in addition to suggestions about precautions about prescribing neuroleptics in young people.
众所周知，抗精神病药停药后会出现停药反应，通过对黑质纹状体通路的影响导致运动障碍。较少被讨论的是“超敏精神病”的概念，它被描述为抗精神病药物停药后迅速出现精神病。虽然已经描述了一些抗精神病药停药后出现超敏精神病的现象，但尚未描述齐拉西酮停药后出现这种现象。此外，本病例报告首次描述了青少年患者停用齐拉西酮后出现这种现象。除了对青少年开抗精神病药时应注意的事项提出建议外，还探讨了超敏精神病的原因。
