Lommatzsch M, Julius P, Lück W, Bier A, Virchow J C
Abteilung für Pneumologie, Universität Rostock.
Pneumologie. 2012 Feb;66(2):67-73. doi: 10.1055/s-0031-1291476. Epub 2012 Jan 16.
Hypertrophic pulmonary osteoarthropathy (often referred to as Marie-Bamberger syndrome) occurs in 1 - 5 % of all patients with non-small cell lung cancer (NSCLC) as a paraneoplastic syndrome. The complete syndrome is characterised by clubbing of the fingers and toes (often without hypoxia) and pain in the joints and tubular bones. On the basis of four clinical cases, this article shows that this syndrome can precede tumour-specific symptoms and that it is still often overlooked by physicians. An early suspicion of this syndrome is of great clinical value because it can lead to a diagnosis of NSCLC at an earlier tumour stage. In addition to the case reports, the current literature on hypertrophic pulmonary osteoarthropathy is reviewed in this article, with special reference to pathogenetic concepts und to therapeutic options.
肥厚性肺骨关节病（常被称为Marie-Bamberger综合征）作为一种副肿瘤综合征，在所有非小细胞肺癌（NSCLC）患者中发生率为1%-5%。完整的综合征表现为手指和脚趾杵状指（常无低氧血症）以及关节和管状骨疼痛。基于四个临床病例，本文表明该综合征可先于肿瘤特异性症状出现，且仍常被医生忽视。早期怀疑该综合征具有重要的临床价值，因为它可在肿瘤早期阶段就促成NSCLC的诊断。除病例报告外，本文还对当前关于肥厚性肺骨关节病的文献进行了综述，特别提及了发病机制概念和治疗选择。
