Zilversmit D B
Circulation. 1979 Sep;60(3):473-85. doi: 10.1161/01.cir.60.3.473.
The hypothesis that plasma chylomicrons in persons who ingest a cholesterol-rich diet are atherogenic is evaluated. Evidence is presented that in humans, and experimental animals, chylomicron remnants as well as low-density lipoproteins are taken up by arterial cells. In persons who do not have familial hyperlipoproteinemia, atherogenesis may occur during the postprandial period. Research directions that may contribute to the evaluation of chylomicron remnants as a risk factor for atherogenesis are discussed. Lipoprotein studies after administration of a test meal containing fat and cholesterol are urgently needed.
对摄入富含胆固醇饮食的人群中血浆乳糜微粒具有致动脉粥样硬化作用这一假说进行了评估。有证据表明，在人类和实验动物中，乳糜微粒残粒以及低密度脂蛋白会被动脉细胞摄取。在没有家族性高脂蛋白血症的人群中，动脉粥样硬化可能在餐后发生。讨论了可能有助于评估乳糜微粒残粒作为动脉粥样硬化危险因素的研究方向。迫切需要在给予含脂肪和胆固醇的试验餐后进行脂蛋白研究。
