Department of Food Science and Biotechnology, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea.
Department of Nano Bio Engineering, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea.
Nutrients. 2024 Aug 27;16(17):2864. doi: 10.3390/nu16172864.
(PK) leaf extract, derived from Korean pine byproducts, holds promise for alleviating postprandial hyperlipidemia. In this study, we investigated the potential of PK leaf extract for modulating postprandial hyperlipidemia in adults with normal or borderline fasting triglyceride levels. In a randomized, double-blind, parallel design, 70 subjects were randomly assigned to either the placebo or PK group for 4 weeks. After 4 weeks of consuming PK leaf extract, the results indicated a trend toward decreased serum apolipoprotein B-100 (ApoB100) levels 2 h after a high-fat challenge. Furthermore, significant improvements were observed in the incremental area under the curve (iAUC) at 0-4 h and 2-4 h compared to baseline, particularly among individuals with a higher body weight (>61.35 kg) and daily caloric intake (>1276.5 kcal). Based on these findings, PK leaf extract may have beneficial effects on postprandial lipoprotein metabolism, especially among individuals with a relatively high body weight and caloric intake.
（PK）叶提取物，源自红松副产物，有望缓解餐后高脂血症。本研究旨在探讨 PK 叶提取物对正常或空腹甘油三酯水平边缘成人餐后高脂血症的调节作用。采用随机、双盲、平行设计，将 70 名受试者随机分为安慰剂组或 PK 组，连续 4 周。4 周后，给予 PK 叶提取物，结果显示，高脂肪负荷后 2 小时血清载脂蛋白 B-100（ApoB100）水平呈下降趋势。此外，与基线相比，0-4 小时和 2-4 小时的曲线下面积增量（iAUC）显著改善，尤其是体重较高（>61.35kg）和每日热量摄入较高（>1276.5kcal）的个体。基于这些发现，PK 叶提取物可能对餐后脂蛋白代谢有益，尤其是在体重和热量摄入较高的个体中。
