Molecular Haematology and Cancer Biology, University College London Institute of Child Health, London WCN1 1EH, UK.
J Immunol. 2012 Feb 15;188(4):1708-16. doi: 10.4049/jimmunol.1102654. Epub 2012 Jan 16.
Activated human blood γδ T cells have also been previously demonstrated to behave as professional APCs, although the processes that control APC function have not been characterized. n this study, we show that the acquisition of potent APC function by human blood γδ T cells is achieved after physical interaction with an Ab-coated target cell, a process that we refer to as licensing. In cancer models, licensing of γδ T cells by tumor-reactive mAbs promotes the uptake of tumor Ags and professional presentation to tumor-reactive αβ T cells. We propose that licensing by Ab is a mechanism whereby the adaptive properties of γδ T cells are induced by their innate functions in a spatially and temporally controlled manner.
已有人证明，活化的人血 γδ T 细胞也可以作为专职抗原提呈细胞（APC）发挥作用，尽管控制 APC 功能的过程尚未被阐明。在本研究中，我们发现，人血 γδ T 细胞获得强大的 APC 功能是在与 Ab 包被的靶细胞发生物理相互作用之后实现的，我们将此过程称为“许可”。在癌症模型中，肿瘤反应性 mAb 对 γδ T 细胞的“许可”作用促进了肿瘤抗原的摄取和向肿瘤反应性 αβ T 细胞的专业呈递。我们提出，Ab 的“许可”作用是 γδ T 细胞的固有功能通过空间和时间控制的方式诱导其适应性特性的一种机制。
