Brandes Marlène, Willimann Katharina, Moser Bernhard
Institute of Cell Biology, University of Bern, CH-3012, Switzerland.
Science. 2005 Jul 8;309(5732):264-8. doi: 10.1126/science.1110267. Epub 2005 Jun 2.
Human gammadelta T cells are considered to play a vital role in protective immunity through cytokine secretion and cytotoxic activity. We report that cells expressing the Vgamma2Vdelta2+-T cell receptor (Vdelta2+ T cells) also display principal characteristics of professional antigen-presenting cells such as dendritic cells. Thus, when activated, these cells efficiently processed and displayed antigens and provided co-stimulatory signals sufficient for strong induction of naïve alphabeta T cell proliferation and differentiation. We suggest that, upon microbial activation, Vdelta2+ T cells participate in the induction of adaptive immune responses and that these cells may be a useful tool in vaccine development and immunotherapy.
人类γδ T细胞被认为通过细胞因子分泌和细胞毒性活性在保护性免疫中发挥重要作用。我们报告称，表达Vγ2Vδ2 + -T细胞受体的细胞（Vδ2 + T细胞）也表现出专业抗原呈递细胞（如树突状细胞）的主要特征。因此，这些细胞在被激活时能有效处理和呈递抗原，并提供足以强烈诱导初始αβ T细胞增殖和分化的共刺激信号。我们认为，在微生物激活后，Vδ2 + T细胞参与适应性免疫反应的诱导，并且这些细胞可能是疫苗开发和免疫治疗中的有用工具。
