Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Chem Commun (Camb). 2012 Feb 21;48(16):2240-2. doi: 10.1039/c2cc17701c. Epub 2012 Jan 18.
A library of 176 human phosphotyrosine-containing peptides was used to establish cell lysate binding profiles in a two colour microarray format. The resulting hits led to the pull-down and identification of biomarkers associated with cancer states.
使用了一个包含 176 个人类磷酸酪氨酸肽的文库,在双色微阵列格式中建立了细胞裂解物结合图谱。由此产生的“命中”结果导致了与癌症状态相关的生物标志物的下拉和鉴定。