Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Sci Signal. 2012 Jan 17;5(207):pe2. doi: 10.1126/scisignal.2002680.
Leucine-rich repeat kinase 2 (LRRK2) is linked to various diseases, including Parkinson's disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible role for LRRK2 in regulating signaling pathways that are linked to the pathogenesis of Crohn's disease. Here, we examine how LRRK2's role as a signaling hub in the cell could lead to diverse pathologies.
富含亮氨酸重复激酶 2（LRRK2）与多种疾病有关，包括帕金森病、癌症和麻风病。LRRK2 敲除小鼠的数据表明，LRRK2 可能在调节与克罗恩病发病机制相关的信号通路中发挥作用。在这里，我们研究 LRRK2 作为细胞信号枢纽的作用如何导致多种病理。
