JNK 诱导的细胞凋亡、代偿性生长与癌症干细胞。
JNK-induced apoptosis, compensatory growth, and cancer stem cells.
机构信息
Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA.
出版信息
Cancer Res. 2012 Jan 15;72(2):379-86. doi: 10.1158/0008-5472.CAN-11-1982.
Abstract
Overwhelming are a set of key stress-responsive kinases that mediate cell apoptosis, which is an important process for tumor suppression. However, JNKs have also been implicated in the malignant transformation and tumorigenesis of cells. This review attempts to reconcile these 2 contradictory functions of JNKs with recent discoveries on the role of JNKs in compensatory growth of neighboring cells and stem cells, which may provide new mechanistic understanding about the role of JNKs in the regulation of cancer stem cells and the pathogenesis of cancers.
摘要
有一组关键的应激反应激酶，它们介导细胞凋亡，这是肿瘤抑制的一个重要过程。然而，JNK 也被牵连到细胞的恶性转化和肿瘤发生中。这篇综述试图将 JNK 的这两种矛盾的功能与最近关于 JNK 在邻近细胞和干细胞代偿性生长中的作用的发现联系起来，这可能为 JNK 在调节癌症干细胞和癌症发病机制中的作用提供新的机制理解。
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1
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Nat Cell Biol. 2011 Jun 19;13(7):762-70. doi: 10.1038/ncb2283.
2
L-threonine regulates G1/S phase transition of mouse embryonic stem cells via PI3K/Akt, MAPKs, and mTORC pathways.L-苏氨酸通过 PI3K/Akt、MAPKs 和 mTORC 通路调控小鼠胚胎干细胞的 G1/S 期转换。
J Biol Chem. 2011 Jul 8;286(27):23667-78. doi: 10.1074/jbc.M110.216283. Epub 2011 May 6.
3
Hallmarks of cancer: the next generation.癌症的特征：下一代。
Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013.
4
Mitogenic signaling from apoptotic cells in Drosophila.果蝇中凋亡细胞的有丝分裂信号
Dev Growth Differ. 2011 Feb;53(2):168-76. doi: 10.1111/j.1440-169X.2010.01225.x.
5
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6
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7
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8
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10
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