Rahman A, Hadi S M, Parish J H
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India.
Carcinogenesis. 1990 Nov;11(11):2001-3. doi: 10.1093/carcin/11.11.2001.
The genotoxic flavonoid, quercetin, was shown to bind to both double-stranded and single-stranded DNA with concomitant changes in absorption spectrum and fluorescence emission spectrum of quercetin. Quercetin and Cu(II) were shown to form a charge transfer complex that decayed in oxygen-dependent reaction(s) and this decay was accelerated by DNA. Analysis of the three component system, DNA--querectin--Cu(II), led to a discussion of the complexes likely to be involved in the initial reactions that lead, ultimately, to strand scission of DNA.
具有基因毒性的类黄酮槲皮素，被证明能与双链和单链DNA结合，同时伴随槲皮素吸收光谱和荧光发射光谱的变化。槲皮素和铜（II）被证明能形成电荷转移复合物，该复合物在氧依赖反应中分解，且DNA能加速这种分解。对DNA - 槲皮素 - 铜（II）三元体系的分析，引发了对可能参与最终导致DNA链断裂的初始反应的复合物的讨论。
