用于有髓轴突靶向刺激的阶梯状细胞外刺激的参数探索
Parameter exploration of staircase-shape extracellular stimulation for targeted stimulation of myelinated axon.
作者信息
Ueno Ayako, Karashima Akihiro, Nakao Mitsuyuki, Katayama Norihiro
机构信息
Biomodeling Laboratory, Department of Applied Information Sciences, Graduate School of Information Sciences, Tohoku University, Sendai, Japan.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:912-5. doi: 10.1109/IEMBS.2011.6090204.
Spatio-temporal dynamics of a mathematical model of myelinated axon in response to staircase-shape extracellular electrical stimulation, which was developed for selective nerve stimulation, is investigated by the computer simulation. It is shown that the response is classified into four types: subthreshold response, cathodic excitation, anodal block and anodal break excitation. Based on the simulation results, simple diagrams representing the response characteristics of the axon are constructed as functions of stimulation parameters and distance between the axon and electrode. The diagram would be useful for determining simulation parameters for dynamic targeted stimulation of myelinated axon.
通过计算机模拟研究了用于选择性神经刺激而开发的有髓轴突数学模型对阶梯状细胞外电刺激的时空动力学。结果表明，该响应可分为四种类型：阈下响应、阴极兴奋、阳极阻滞和阳极断相兴奋。基于模拟结果，构建了表示轴突响应特性的简单图表，作为刺激参数和轴突与电极之间距离的函数。该图表将有助于确定有髓轴突动态靶向刺激的模拟参数。
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