Zhang Guanqun, Gao Mingwu, Mukkamala Ramakrishna
Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:4291-4. doi: 10.1109/IEMBS.2011.6091065.
We proposed a technique for estimating beat-to-beat pulse transit time (PTT) from central and peripheral blood pressure or flow waveforms based on an arterial tube-load model of wave reflection. The technique effectively estimates PTT from the entire waveforms after mathematically eliminating the reflected wave. So, unlike the conventional foot-to-foot detection technique, this technique should be robust to artifact while revealing the true PTT (i.e., the PTT in absence of wave reflection). We compared the two techniques, as applied to blood pressure and flow waveforms, in terms of the ability of their PTT estimates to correlate with blood pressure (a) during baseline (for which the naturally occurring beat-to-beat changes were small), (b) during low heart rate (wherein wave reflection was profound), and (c) in the presence of actual measurement artifact. In all three cases, the PTT estimates of the arterial tube-load model technique yielded markedly superior correlation to blood pressure.
我们提出了一种基于波反射的动脉管负载模型，从中心和外周血压或血流波形估计逐搏脉搏传输时间（PTT）的技术。该技术在数学上消除反射波后，能有效地从整个波形中估计PTT。因此，与传统的脚对脚检测技术不同，该技术在揭示真实PTT（即无波反射时的PTT）的同时，对伪影应具有鲁棒性。我们将这两种技术应用于血压和血流波形，比较了它们的PTT估计值与血压的相关性，具体包括：（a）在基线期间（此时自然发生的逐搏变化较小）；（b）在低心率期间（此时波反射明显）；以及（c）在存在实际测量伪影的情况下。在所有这三种情况下，动脉管负载模型技术的PTT估计值与血压的相关性明显更高。
