Kroker R, Anwer M S, Hegner D
Aktuelle Gerontol. 1977 Oct;7(10):539-45.
The age dependence of bile acid metabolism in rats was investigated and the following results were obtained. 1) Synthesis rate, pool size and total secretion decreased in old rats (24 month) significantly compared to young rats (6 weeks). 2) The quotient of taurine to glycine conjugates is is significant lower in old rats compared to young rats. 3) The lithogenic index remains unchanged in all age groups. 4) Old rats show a significantly higher Km for cholic acid uptake, whereas the diffusion coefficient is decreased. The possible influence of humoral factors on age dependent regulations of bile metabolism is discussed.
研究了大鼠胆汁酸代谢的年龄依赖性，并获得了以下结果。1）与年轻大鼠（6周龄）相比，老年大鼠（24月龄）的合成速率、池大小和总分泌量显著降低。2）老年大鼠中牛磺酸与甘氨酸结合物的商显著低于年轻大鼠。3）所有年龄组的致石指数均保持不变。4）老年大鼠胆酸摄取的Km显著更高，而扩散系数降低。讨论了体液因素对胆汁代谢年龄依赖性调节的可能影响。
