Kim Sanggyun, Takahashi Kazutaka, Hatsopoulos Nicholas G, Coleman Todd P
Department of Electrical and Computer Engineering, University of Illinois, Urbana-Champaign, 1308 W MainUrbana, IL 61801, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:7278-81. doi: 10.1109/IEMBS.2011.6091697.
It was previously shown that beta oscillations of local field potentials in the arm area of the primary motor cortex (MI) of nonhuman primates propagate as travelling waves across MI of monkeys during movement preparation and execution and are believed to subserve cortical information transfer. To investigate the information transfer and its change over time at the single-cell level, we analyzed simultaneously recorded multiple MI neural spike trains of a monkey using a Granger causality measure for point process models before and after visual cues instructing the onset of reaching movements. In this analysis, we found that more pairs of neurons showed information transfer between them after appearances of upcoming movement targets than before, and the directions of the information transfer across neurons in MI were coincident with the directions of the propagating waves. These results suggest that the neuron pairs identified in the current study are the candidates of neurons that travel with spatiotemporal dynamics of beta oscillations in the MI.
先前的研究表明，在运动准备和执行过程中，非人类灵长类动物初级运动皮层（MI）手臂区域局部场电位的β振荡以行波形式在猴子的MI中传播，并且被认为有助于皮层信息传递。为了在单细胞水平上研究信息传递及其随时间的变化，我们使用点过程模型的格兰杰因果关系度量，分析了在视觉提示指示伸手运动开始之前和之后同时记录的一只猴子的多个MI神经尖峰序列。在这项分析中，我们发现与即将出现的运动目标出现之前相比，更多的神经元对在目标出现之后表现出它们之间的信息传递，并且MI中跨神经元的信息传递方向与传播波的方向一致。这些结果表明，在本研究中鉴定出的神经元对是与MI中β振荡的时空动态一起活动的神经元的候选者。
