Hakusui S, Takahashi A, Sugiyama Y, Koike Y, Hasegawa Y
Department of Neurology, Nagoya University School of Medicine.
Rinsho Shinkeigaku. 1990 Jun;30(6):672-4.
In order to clarify the effect of arginine vasopressin (AVP) on postprandial hypotension (PPH) in patients with multiple system atrophy, a loading test of 75 g glucose in 225 ml water was performed during infusion of AVP (0.3 U/min). AVP (0.3 U/min) infusion prior to the loading was significantly effective for PPH in all patients: PPH following to oral intake of glucose was completely prevented. We conclude that infusion of AVP maintained circulating systemic blood volumes by reduced portal venous flow (after a reduction of portal venous inflow) as a result of vasoconstrictive effect of AVP on the splanchnic vessels in patients with PPH.
为了阐明精氨酸加压素（AVP）对多系统萎缩患者餐后低血压（PPH）的影响，在输注AVP（0.3 U/分钟）期间进行了75 g葡萄糖溶于225 ml水的负荷试验。在负荷试验前输注AVP（0.3 U/分钟）对所有患者的PPH均有显著效果：口服葡萄糖后的PPH完全得到预防。我们得出结论，由于AVP对PPH患者内脏血管的血管收缩作用，输注AVP通过减少门静脉血流（在门静脉流入减少后）维持循环系统血容量。
