[来自阔叶乌檀的三萜类化合物和甾醇]

[Triterpenes and sterols from Nauclea latifolia].

作者信息

Wang Ling, Zhang Chaofeng, Layba Mara, Zhang Mian

机构信息

Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Ministry of Education, Research Department of Pharmacognosy, China Pharmaceutical University, Nanjing 211198, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2011 Sep;36(18):2511-4.

PMID:22256756

Abstract

OBJECTIVE

To investigate the chemical constituents of Nauclea latifolia, which is an African folk medicine and collected from Guinea.

METHOD

The chemical constituents were isolated by silica gel and Sephadex LH-20 column chromatographies, and structurally elucidated by spectral evidence together with physiochemical properties.

RESULT

Twelve compounds including 8 triterpenes and 4 sterols were isolated from the roots of N. latifolia, and their structures were defined as 24-en-cycloartenone (1), ursolic aldehyde (2), quinovic acid (3), rotundic acid (4), 3beta,19alpha,23,24-tetrahydroxyurs-12-en-28-oic acid (5), pyrocincholic acid 3beta-O-beta-D-fucopyranoside (6), quinovic acid 3beta-O-beta-D-glucopyranoside (7), quinovic acid-3b-O-D-glucopyranosyl-(28-->1)-beta-D-glucopyranosyl ester (8), beta-sitosterol (9), stigmastan-3,6-dione (10), stigmast-4-en-6beta-ol-3-one (11) and daucosterol (12) .

CONCLUSION

All compounds except for 4,9, andl2 are isolated from this plant for the fist time, while compounds 2, 6, 10, and 11 are isolated from the genus Nauclea for the first time.

摘要

目的

研究从几内亚采集的非洲民间药物阔叶乌檀的化学成分。

方法

采用硅胶柱色谱和葡聚糖凝胶LH - 20柱色谱分离化学成分，并通过光谱数据和理化性质对其结构进行鉴定。

结果

从阔叶乌檀根中分离得到12个化合物，包括8个三萜类化合物和4个甾醇类化合物，其结构分别鉴定为24 - 烯环阿尔廷酮（1）、熊果酸醛（2）、奎诺酸（3）、圆椎酸（4）、3β，19α，23，24 - 四羟基乌苏 - 12 - 烯 - 28 - 酸（5）、焦金鸡纳酸3β - O - β - D - 岩藻吡喃糖苷（6）、奎诺酸3β - O - β - D - 葡萄糖吡喃糖苷（7）、奎诺酸 - 3β - O - D - 吡喃葡萄糖基 -（28→1）- β - D - 吡喃葡萄糖酯（8）、β - 谷甾醇（9）、豆甾烷 - 3，6 - 二酮（10）、豆甾 - 4 - 烯 - 6β - 醇 - 3 - 酮（11）和胡萝卜苷（12）。