Wu Bin, Zhao Shuzhi, Wang Xiumin, Dong Qiqian, Zheng Guoqing
Department of Neurology, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China.
Zhongguo Zhong Yao Za Zhi. 2011 Sep;36(18):2588-91.
Parkinson's disease (PD) is a common degenerative disease of the central nervous system, but no drug has been found to be surely able to protect neurons so far, delay onset or slow progression of the disease. Currently there are a variety of Chinese formulas, single herb medicines, active fractions and monomers showed prophylactic and therapeutic effect on PD animal models. The mechanisms include protection of substantia nigra cells, improvement of neurotransmitter content, anti-oxidation, immune regulation, enhancement of Western medicine efficacy, reduction of side effects, etc. All these mechanisms may play integrated effect and slow disease progression. In particular, Chinese medicine compound may have some advantages in neuroprotective treatment of PD, because a variety of active ingredients can exert multi-links, multi-levels and multi-targets integrated regulation effect on human body. However, the level and standard of Chinese medicine studies on PD animal still need to be improved.
帕金森病（PD）是一种常见的中枢神经系统退行性疾病，但目前尚未发现有药物能够确切地保护神经元、延缓疾病的发作或减缓其进展。目前，多种中药方剂、单味中药、有效部位及单体对帕金森病动物模型均显示出预防和治疗作用。其作用机制包括保护黑质细胞、改善神经递质含量、抗氧化、免疫调节、增强西药疗效、减少副作用等。所有这些机制可能共同发挥作用，减缓疾病进展。特别是中药复方在帕金森病的神经保护治疗中可能具有一定优势，因为多种活性成分可对人体发挥多环节、多层次、多靶点的综合调节作用。然而，针对帕金森病动物的中药研究水平和标准仍有待提高。
