Siebert J R, Lemire R J, Cohen M M
Department of Pathology, University of Washington, Seattle.
Clin Perinatol. 1990 Sep;17(3):569-95.
This overview of congenital defects of the CNS has emphasized pathogenesis. As developmental pathways continue to be elucidated, this approach remains to an extent hypothetical. When, however, an understanding of the features of morphogenesis and dysmorphogenesis helps to indicate time of onset or to elucidate causal factors, important steps toward the prevention of birth defects are taken.
对中枢神经系统先天性缺陷的这一概述着重阐述了发病机制。随着发育途径不断得到阐明，这种方法在一定程度上仍属假设性的。然而，当对形态发生和畸形发生特征的理解有助于指明发病时间或阐明因果因素时，就朝着预防出生缺陷迈出了重要的步伐。
