Takci Zennure, Ozoguz Pinar
Department of Dermatology, Ankara Kecioren Research and Training Hospital, Ankara, Turkey.
Cutan Ocul Toxicol. 2012 Dec;31(4):332-4. doi: 10.3109/15569527.2011.647178. Epub 2012 Jan 18.
Tinzaparin sodium is a low molecular weight heparin formed by the enzymatic degradation of porcine unfractionated heparin, and is effective in the prevention and treatment of thromboembolic disease. We report a 31-year-old female patient with a history of recurrent pregnancy loss due to thrombophilia, who developed nail discoloration after 8 weeks of tinzaparin sodium therapy. No other pigmentation was found elsewhere on the skin, mucous membranes, teeth, or sclerae. To our knowledge, nail pigmentation following tinzaparin sodium therapy is an unknown side effect and has not been reported previously in the English literature.
替扎肝素钠是一种通过对猪源未分级肝素进行酶促降解而形成的低分子量肝素，对血栓栓塞性疾病的预防和治疗有效。我们报告一名31岁女性患者，有因血栓形成倾向导致反复流产的病史，在接受替扎肝素钠治疗8周后出现指甲变色。在皮肤、黏膜、牙齿或巩膜的其他部位未发现其他色素沉着。据我们所知，替扎肝素钠治疗后出现指甲色素沉着是一种未知的副作用，英文文献中此前未见报道。
