ABC转运蛋白在癌症化疗中的作用。
Role of ABC transporters in cancer chemotherapy.
作者信息
Sun Yue-Li, Patel Atish, Kumar Priyank, Chen Zhe-Sheng
机构信息
Department of Pharmaceutical Sciences, St. John's University, Jamaica, NY 11439, USA.
出版信息
Chin J Cancer. 2012 Feb;31(2):51-7. doi: 10.5732/cjc.011.10466. Epub 2012 Jan 17.
Abstract
Multidrug resistance (MDR) in cancer cells can significantly attenuate the response to chemotherapy and increase the likelihood of mortality. The major mechanism involved in conferring MDR is the overexpression of ATP-binding cassette (ABC) transporters, which can increase efflux of drugs from cancer cells, thereby decreasing intracellular drug concentration. Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs. This editorial highlights some major findings related to ABC transporters and current strategies to overcome MDR.
摘要
癌细胞中的多药耐药性（MDR）可显著减弱对化疗的反应并增加死亡可能性。赋予MDR的主要机制是ATP结合盒（ABC）转运蛋白的过表达，其可增加癌细胞中药物的外排，从而降低细胞内药物浓度。ABC转运蛋白调节剂有增强抗癌药物疗效的潜力。这篇社论重点介绍了与ABC转运蛋白相关的一些主要发现以及当前克服MDR的策略。
相似文献
1
Role of ABC transporters in cancer chemotherapy.
Chin J Cancer. 2012 Feb;31(2):51-7. doi: 10.5732/cjc.011.10466. Epub 2012 Jan 17.
2
Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2.
Cancer Res. 2008 Oct 1;68(19):7905-14. doi: 10.1158/0008-5472.CAN-08-0499.
3
ATP-binding cassette efflux transporters and MDR in cancer.
Drug Discov Today. 2023 May;28(5):103537. doi: 10.1016/j.drudis.2023.103537. Epub 2023 Feb 16.
4
Multidrug resistance: retrospect and prospects in anti-cancer drug treatment.
Curr Med Chem. 2006;13(16):1859-76. doi: 10.2174/092986706777585077.
5
Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties.
Br J Pharmacol. 2009 Oct;158(4):1153-64. doi: 10.1111/j.1476-5381.2009.00383.x. Epub 2009 Sep 28.
6
Overcoming Multidrug Resistance: Flavonoid and Terpenoid Nitrogen-Containing Derivatives as ABC Transporter Modulators.
Molecules. 2020 Jul 24;25(15):3364. doi: 10.3390/molecules25153364.
7
β-carotene reverses multidrug resistant cancer cells by selectively modulating human P-glycoprotein function.
Phytomedicine. 2016 Mar 15;23(3):316-23. doi: 10.1016/j.phymed.2016.01.008. Epub 2016 Feb 6.
8
ABC transporters in multidrug resistance and pharmacokinetics, and strategies for drug development.
Curr Pharm Des. 2014;20(5):793-807. doi: 10.2174/138161282005140214165212.
9
Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance.
Anticancer Agents Med Chem. 2015;15(4):423-32.
10
Hedgehog signaling regulates drug sensitivity by targeting ABC transporters ABCB1 and ABCG2 in epithelial ovarian cancer.
Mol Carcinog. 2014 Aug;53(8):625-34. doi: 10.1002/mc.22015. Epub 2013 Feb 19.
引用本文的文献
1
Chitosan Nanoparticles for Topical Drug Delivery in Chemotherapy-Induced Alopecia: A Comparative Study of Five Repurposed Pharmacological Agents.
Pharmaceuticals (Basel). 2025 Jul 21;18(7):1071. doi: 10.3390/ph18071071.
2
Wnt signal pathways: new mechanistic approaches and clinical horizons in cancer therapy.
Med Oncol. 2025 Jul 8;42(8):314. doi: 10.1007/s12032-025-02868-1.
3
ABCG2 protein expression in tumors of patients with non-resectable pancreatic cancer treated with gemcitabine and -paclitaxel.
Front Oncol. 2025 Jun 6;15:1558184. doi: 10.3389/fonc.2025.1558184. eCollection 2025.
4
Morellic Acid B Overcomes ‑Glycoprotein-Mediated Multidrug Resistance in Hepatocellular Carcinoma Cells via Regulation of MAPK/NF-kB Signaling Pathways.
ACS Omega. 2025 May 22;10(21):21120-21127. doi: 10.1021/acsomega.4c09692. eCollection 2025 Jun 3.
5
Current and future of targeted therapies against BCR::ABL kinases.
J Egypt Natl Canc Inst. 2025 Apr 7;37(1):12. doi: 10.1186/s43046-025-00263-5.
6
ABCG8‑mediated sterol efflux increases cancer cell progression via the LRP6/Wnt/β‑catenin signaling pathway in radiotherapy‑resistant MDA‑MB‑231 triple‑negative breast cancer cells.
Int J Mol Med. 2025 May;55(5). doi: 10.3892/ijmm.2025.5521. Epub 2025 Mar 21.
7
Tumor-Targeted Magnetic Micelles for Magnetic Resonance Imaging, Drug Delivery, and Overcoming Multidrug Resistance.
ACS Omega. 2024 Dec 9;9(50):49566-49579. doi: 10.1021/acsomega.4c07132. eCollection 2024 Dec 17.
8
Therapeutic targeting potential of the protein lysine and arginine methyltransferases to reverse cancer chemoresistance.
Front Mol Biosci. 2024 Dec 5;11:1455415. doi: 10.3389/fmolb.2024.1455415. eCollection 2024.
9
Unsymmetrical Bisacridines' Interactions with ABC Transporters and Their Cellular Impact on Colon LS 174T and Prostate DU 145 Cancer Cells.
Molecules. 2024 Nov 26;29(23):5582. doi: 10.3390/molecules29235582.
10
The Drug Transporter P-Glycoprotein and Its Impact on Ceramide Metabolism-An Unconventional Ally in Cancer Treatment.
Int J Mol Sci. 2024 Sep 11;25(18):9825. doi: 10.3390/ijms25189825.
本文引用的文献
1
Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology.
Chin J Cancer. 2012 Feb;31(2):100-9. doi: 10.5732/cjc.011.10326. Epub 2012 Jan 9.
2
Multidrug resistance associated proteins in multidrug resistance.
Chin J Cancer. 2012 Feb;31(2):58-72. doi: 10.5732/cjc.011.10329. Epub 2011 Nov 18.
3
Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cells.
Chin J Cancer. 2012 Feb;31(2):110-8. doi: 10.5732/cjc.011.10327. Epub 2011 Nov 18.
4
Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression.
Chin J Cancer. 2012 Feb;31(2):73-99. doi: 10.5732/cjc.011.10320. Epub 2011 Nov 18.
5
Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases.
FEBS J. 2011 Sep;278(18):3226-45. doi: 10.1111/j.1742-4658.2011.08235.x. Epub 2011 Aug 1.
6
SnapShot: Protein-protein interaction networks.
Cell. 2011 Mar 18;144(6):1000, 1000.e1. doi: 10.1016/j.cell.2011.02.025.
7
Revisiting the ABCs of multidrug resistance in cancer chemotherapy.
Curr Pharm Biotechnol. 2011 Apr;12(4):570-94. doi: 10.2174/138920111795164048.
8
Lapatinib and breast cancer: current indications and outlook for the future.
Expert Rev Anticancer Ther. 2010 Aug;10(8):1171-82. doi: 10.1586/era.10.113.
9
Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance.
Drug Resist Updat. 2010 Aug-Oct;13(4-5):109-18. doi: 10.1016/j.drup.2010.07.001. Epub 2010 Aug 9.
10
Logic-based models for the analysis of cell signaling networks.
Biochemistry. 2010 Apr 20;49(15):3216-24. doi: 10.1021/bi902202q.
Zotero 插件