Li Shuaizhang, Zhang Wen, Yin Xuejiao, Xing Shilai, Xie Heidi Qunhui, Cao Zhengyu, Zhao Bin
Research Center for Eco- Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Anticancer Agents Med Chem. 2015;15(4):423-32.
The ABC (ATP-binding cassette) transporter is one of the largest and most ancient protein families with members functioning from protozoa to human. The resistance of cancer and tumor cells to anticancer drugs is due to the over-expression of some ABC transporters, which may finally lead to chemotherapy failure. The mouse ABC transporters are classified into seven subfamilies by phylogenetic analysis. The mouse ABC transporter gene, alias, chromosomal location and function have been determined. Within the ABC super-family, the MDR transporters (Abcb1, Abcc1, Abcg2) in mouse models have been proved to be valuable to investigate the biochemistry and physiological functions. This review concentrates on the multidrug resistance of mouse ABC transporters in cancer and tumor cells.
ABC（ATP结合盒）转运蛋白是最大且最古老的蛋白质家族之一，其成员在从原生动物到人类的生物中发挥作用。癌症和肿瘤细胞对抗癌药物的耐药性是由于某些ABC转运蛋白的过度表达，这最终可能导致化疗失败。通过系统发育分析，小鼠ABC转运蛋白被分为七个亚家族。小鼠ABC转运蛋白基因、别名、染色体定位和功能已被确定。在ABC超家族中，已证明小鼠模型中的MDR转运蛋白（Abcb1、Abcc1、Abcg2）对于研究生物化学和生理功能具有重要价值。本综述集中探讨小鼠ABC转运蛋白在癌症和肿瘤细胞中的多药耐药性。
