静脉注射肼屈嗪对重度子痫前期孕妇血浆一氧化氮水平的影响：一项初步研究。

Effect of intravenous hydralazine infusion on maternal plasma nitric oxide levels in gestations complicated with severe preeclampsia: a pilot study.

机构信息

Biomedical Center, Universidad Central del Ecuador, Quito, Ecuador.

出版信息

Arch Gynecol Obstet. 2012 Apr;285(4):1183-7. doi: 10.1007/s00404-012-2217-6. Epub 2012 Jan 19.

DOI:10.1007/s00404-012-2217-6

PMID:22258304

Abstract

AIM

To investigate the effect of intravenous hydralazine infusion on maternal nitric oxide (NO) levels.

METHODS

This pilot study comprised 40 (n = 40) gestations complicated with severe preeclampsia to whom maternal plasma NO levels were determined by chemiluminescence before and after hydralazine administration. Blood pressure values were concomitantly assessed.

RESULTS

After 20 min of intravenous hydralazine infusion blood pressure values decrease significantly in term and preterm gestations. This was accompanied by an overall significant decrease in mean plasma NO values (38.7 ± 12.9 to 35.4 ± 13.9 μmol/L, p < 0.05). Despite this, NO values decreased in 67.5% of cases (a 17.6% from baseline) and increased in 32.5% (a 14.8% from baseline) (p < 0.05 for both). Blood pressure decrease (%) was lower (systolic and diastolic) among those displaying a NO decrement than in the increment group. Interestingly, gestational age was higher in the group displaying decreased NO; however, this did not reach statistical significance (37.5 ± 2.7 vs. 35.9 ± 2.8 weeks, p = 0.08).

CONCLUSION

The results of this study fail to demonstrate a similar NO secretion after hydralazine infusion in women with severe preeclampsia.

摘要

目的

探讨静脉注射肼屈嗪对母体一氧化氮（NO）水平的影响。

方法

本初步研究纳入 40 例（n = 40）严重子痫前期孕妇，在给予肼屈嗪前和后通过化学发光法测定母体血浆 NO 水平。同时评估血压值。

结果

静脉注射肼屈嗪 20 分钟后，足月和早产孕妇的血压值显著下降。这伴随着平均血浆 NO 值的整体显著下降（38.7 ± 12.9 至 35.4 ± 13.9 μmol/L，p < 0.05）。尽管如此，NO 值在 67.5%的病例中下降（比基线下降 17.6%），在 32.5%的病例中增加（比基线增加 14.8%）（两者均 p < 0.05）。与增加组相比，NO 值降低的患者血压下降（收缩压和舒张压）幅度较低。有趣的是，NO 值降低组的妊娠年龄较高；然而，这并未达到统计学意义（37.5 ± 2.7 与 35.9 ± 2.8 周，p = 0.08）。