Sames K
Aktuelle Gerontol. 1977 Oct;7(10):555-61.
In the centre of aged human rib cartilage, a yellowing degenerative zone is seen, while in a circular peripheral region the tissue remains unchanged. The cartilage of the 12th rib shows decrease in diameter towards its free end. It therefore was used as a model to find out wether there is a critical diameter of the diffusion stretch leading to a degeneration of the centre. This stretch was to be compared with the diameter of the peripheral circular zone. Cartilage of the second rib was used for comparison. The length of the free end showing no degeneration was 2,5- to 4 mm. Its radius was longer than the diameter of the circular zone in the middle part of the 12th rib cartilage, but this was not found in the second rib cartilage nor at the base of the 12th rib cartilage. The difference between the cartilage of differing individuals was more striking than the difference found between all cross sections of the second and 12th rib cartilage. The length of the diffusion stretch is thought to be an accessorial cause of aging besides the age changes of the cells and intercellular matrix, but not the only cause.
在老年人类肋骨软骨的中心，可以看到一个发黄的退变区域，而在圆形的周边区域，组织保持不变。第12肋软骨向其自由端的直径逐渐减小。因此，它被用作模型来研究导致中心退变的扩散伸展是否存在临界直径。这个伸展要与周边圆形区域的直径进行比较。第二肋软骨用于比较。未发生退变的自由端长度为2.5至4毫米。其半径比第12肋软骨中部圆形区域的直径长，但在第二肋软骨或第12肋软骨基部未发现这种情况。不同个体之间软骨的差异比第二肋软骨和第12肋软骨所有横截面之间的差异更显著。扩散伸展的长度被认为是除细胞和细胞间基质的年龄变化之外衰老的一个辅助原因，但不是唯一原因。
