Modification by SQ 14225 of blood pressure and adrenal catecholamine response to hemorrhage.

SQ 14225 infusion to cats exposed to hemorrhage suppressed adrenomedullary catecholamine release. The immediate compensatory blood pressure response was unaffected, while the later compensatory response was of a higher magnitude in intact cats that in SQ 14225-treated animals. Adrenal gland blood flow was better preserved in SQ 14225-treated hemorrhaged cats than in cats exposed to hemorrhage only. These data emphasize the role of angiotensin II in adrenal catecholamine and blood pressure responses to hemorrhage.