Karaiskos Theodoros, Tomos Periklis, Asouhidou Irene, Nikiteas Nikolaos, Kontakiotis Theodoros, Papalois Apostolos
Department of Cardiothoracic Surgery, G. Papanikolaou General Hospital, Thessaloniki, Greece.
J Cardiothorac Surg. 2012 Jan 19;7:7. doi: 10.1186/1749-8090-7-7.
Radiofrequency ablation (RFA) is a thermal energy delivery system used for coagulative cellular destruction of small tumors through percutaneous or intraoperative application of its needle electrode to the target area, and for assisting partial resection of liver and kidney. We tried to evaluate the regional oxidative and pre-inflammatory stress of RFA-assisted wedge lung resection, by measuring the MDA and tumor Necrosis Factor Alpha (TNF-α) concentration in the resected lung tissue of a swine model.
Fourteen white male swines, divided in two groups, the RFA-group and the control group (C-group) underwent a small left thoracotomy and wedge lung resection of the lingula. The wedge resection in the RFA-group was performed using the RFA technique whereas in C-group the simple "cut and sew" method was performed. We measured the malondialdehyde (MDA) and TNF-α concentration in the resected lung tissue of both groups.
In C-group the MDA mean deviation rate was 113 ± 42.6 whereas in RFA-group the MDA mean deviation rate was significantly higher 353 ± 184 (p = 0.006). A statistically significant increase in TNF-α levels was also observed in the RFA-group (5.25 ± 1.36) compared to C-group (mean ± SD = 8.48 ± 2.82) (p = 0.006).
Our data indicate that RFA-assisted wedge lung resection in a swine model increases regional MDA and TNF-a factors affecting by this oxidative and pre-inflammatory stress of the procedure. Although RFA-assisted liver resection can be well tolerated in humans, the possible use of this method to the lung has to be further investigated in terms of regional and systemic reactions and the feasibility of performing larger lung resections.
射频消融（RFA）是一种热能传递系统，通过经皮或术中将针状电极应用于目标区域，用于对小肿瘤进行凝固性细胞破坏，并辅助肝脏和肾脏的部分切除。我们试图通过测量猪模型切除肺组织中的丙二醛（MDA）和肿瘤坏死因子α（TNF-α）浓度，来评估RFA辅助楔形肺切除术中的局部氧化和炎症前应激。
14只白色雄性猪分为两组，即RFA组和对照组（C组），接受左胸小切口和舌叶楔形肺切除术。RFA组采用RFA技术进行楔形切除，而C组采用简单的“切割缝合”方法。我们测量了两组切除肺组织中的丙二醛（MDA）和TNF-α浓度。
C组MDA平均偏差率为113±42.6，而RFA组MDA平均偏差率显著更高，为353±184（p = 0.006）。与C组（平均±标准差= 8.48±2.82）相比，RFA组的TNF-α水平也有统计学显著升高（5.25±1.36）（p = 0.006）。
我们的数据表明，猪模型中RFA辅助楔形肺切除术会增加局部MDA和TNF-a因子，这受该手术的氧化和炎症前应激影响。尽管RFA辅助肝切除术在人类中耐受性良好，但该方法在肺部的可能应用，在局部和全身反应以及进行更大范围肺切除术的可行性方面，仍需进一步研究。
