De Scalzi M, Becucci A, De Leonardis V, Lusini C, Pieri A, Cinelli P
Cattedra di Patologia Speciale Medica I, Università degli Studi, Firenze, Italy.
Chronobiologia. 1990 Jul-Sep;17(3):195-200.
The relation between heart rate and QT interval is the result of the autonomic nervous system control on cardiac function in healthy adults; accordingly, chronobiological studies have shown that adult subjects have circadian rhythms of heart rate (expressed as R-R interval) and QT interval in phase. We have employed chronobiological methods to study heart rate and QT interval relation in 10 newborn infants, who are known to have an immature cardiac control. Findings from this study indicate that not all the newborns show circadian rhythms of heart rate and QT interval and that when both rhythms are present they do not correlate like in the adults. Likely, this lack of relationship between heart rate and QT interval in newborns is due to different maturational stages of the newborns studied. As a practical implication, in newborn infants, mathematical correction of QT interval by heart rate is not a reliable method.
在健康成年人中，心率与QT间期的关系是自主神经系统对心脏功能控制的结果；因此，时间生物学研究表明，成年受试者的心率（以R-R间期表示）和QT间期具有同步的昼夜节律。我们采用时间生物学方法对10名已知心脏控制功能不成熟的新生儿的心率与QT间期关系进行了研究。这项研究的结果表明，并非所有新生儿都表现出心率和QT间期的昼夜节律，而且当两种节律都存在时，它们并不像成年人那样具有相关性。新生儿心率与QT间期之间缺乏这种关系可能是由于所研究新生儿的成熟阶段不同。实际应用中，在新生儿中，通过心率对QT间期进行数学校正不是一种可靠的方法。
