Cell Regulation Department, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Withington, Manchester M20 4BX, UK.
Biochem Soc Trans. 2012 Feb;40(1):230-4. doi: 10.1042/BST20110630.
MAPK (mitogen-activated protein kinase) pathways are among the most frequently deregulated signalling events in cancer. Among the critical targets of MAPK activities are members of the AP-1 (activator protein 1) transcription factor, a dimeric complex consisting of Jun, Fos, Maf and ATF (activating transcription factor) family DNA-binding proteins. Depending on the cellular context, the composition of the dimeric complexes determines the regulation of growth, survival or apoptosis. JNK (c-Jun N-terminal kinase), p38 and a number of Jun and Fos family proteins have been analysed for their involvement in oncogenic transformation and tumour formation. These data are also emerging for the ATF components of the AP-1 factor. The aim of the present review is to provide an overview of the functions of two ATF family proteins, ATF2 and ATF7, in mammalian development and their potential functions in tumour formation.
丝裂原活化蛋白激酶（MAPK）途径是癌症中最常被失调的信号事件之一。MAPK 活性的关键靶标之一是 AP-1（激活蛋白 1）转录因子的成员，它是由 Jun、Fos、Maf 和 ATF（激活转录因子）家族 DNA 结合蛋白组成的二聚体复合物。根据细胞环境的不同，二聚体复合物的组成决定了生长、存活或凋亡的调节。JNK（c-Jun N-末端激酶）、p38 和许多 Jun 和 Fos 家族蛋白已被分析其在致癌转化和肿瘤形成中的作用。这些数据也正在为 AP-1 因子的 ATF 成分出现。本综述的目的是提供对两种 ATF 家族蛋白 ATF2 和 ATF7 在哺乳动物发育中的功能的概述及其在肿瘤形成中的潜在功能。
