National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India.
Biochem Soc Trans. 2012 Feb;40(1):279-81. doi: 10.1042/BST20110618.
The IP3R (inositol 1,4,5-trisphosphate receptor) releases Ca2+ from the ER (endoplasmic reticulum) store upon binding to its ligand InsP3, which is thought to be generated by activation of certain membrane-bound G-protein-coupled receptors in Drosophila. Depletion of Ca2+ in the ER store also activates SOCE (store-operated Ca2+ entry) from the extracellular milieu across the plasma membrane, leading to a second rise in cytosolic Ca2+, which is then pumped back into the ER. The role of the IP3R and SOCE in mediating Ca2+ homoeostasis in neurons, their requirement in neuronal function and effect on neuronal physiology and as a consequence behaviour, are reviewed in the present article.
三磷酸肌醇受体（inositol 1,4,5-trisphosphate receptor）在与配体 InsP3 结合时会从内质网（endoplasmic reticulum）库中释放 Ca2+，人们认为 InsP3 是由果蝇中某些膜结合的 G 蛋白偶联受体的激活产生的。内质网库中 Ca2+的耗竭也会激活质膜外细胞外环境中的 SOCE（store-operated Ca2+ entry），导致细胞浆 Ca2+的第二次升高，然后再被泵回内质网。本文综述了 IP3R 和 SOCE 在神经元中调节 Ca2+动态平衡中的作用、它们在神经元功能中的必要性以及对神经元生理学的影响，以及由此产生的行为。
