Department of Chemistry, Annamalai University, Annamalainagar, Tamilnadu 608 002, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2012 Apr;89:194-200. doi: 10.1016/j.saa.2011.12.060. Epub 2011 Dec 29.
Bioactive imidazole derivatives were synthesized and characterized by spectral techniques. The photophysical properties of imidazole derivatives were studied in several solvents. The observed spectral shift is attributed to a loss of planarity in the excited state provided by the non-co-planarity of the aryl rings attached to C(2) and N(1) atoms of the imidazole ring. The observed solvatochromic shifts were analyzed in detail by Kamlet-Taft and Catalan parameters. The interaction between bioactive imidazole derivative and bovine serum albumin (BSA) was also investigated.
合成了具有生物活性的咪唑衍生物，并通过光谱技术对其进行了表征。研究了咪唑衍生物在几种溶剂中的光物理性质。观察到的光谱位移归因于连接到咪唑环的 C(2)和 N(1)原子上的芳环的非共面性导致的激发态的平面性丧失。详细分析了观察到的溶剂化变色位移的 Kamlet-Taft 和 Catalan 参数。还研究了生物活性咪唑衍生物与牛血清白蛋白（BSA）之间的相互作用。
