Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers University Memory Center, University of Angers, UNAM, Angers, France. CeAnnweiler @ chu-angers.fr
Dement Geriatr Cogn Disord. 2011;32(4):273-8. doi: 10.1159/000334944. Epub 2012 Jan 19.
Hypovitaminosis D has been cross-sectionally associated with dementia and stroke. The objective of this longitudinal study was to determine whether serum vitamin D deficiency at baseline could predict the onset of non-Alzheimer dementias (NAD) within 7 years among older women.
Forty high-functioning older women (78.4 years, 76.4/82.0; median, 25th/75th percentile) from the EPIDOS Toulouse study were divided into two groups based on vitamin D deficiency (i.e., serum 25-hydroxyvitamin D <10 ng/ml) at baseline. At the end of the 7-year follow-up period, women matching the DSM-IV but not the NINCDS-ADRDA criteria were diagnosed with NAD while those matching the NINCDS-ADRDA criteria were considered to have Alzheimer's disease (AD). Subtle cognitive impairments at baseline, cardiovascular risk factors and Parkinson's disease were used as potential confounders.
NAD was reported in 6 women (82.8 years, 80.6/86.0) after 7 years of follow-up. More NAD were observed in women with vitamin D deficiency (p = 0.023). There was no between-group difference regarding the onset of AD (p = 0.332). We found an association between vitamin D deficiency at baseline and the onset of NAD (adjusted odds ratio = 19.57, p = 0.042). Conversely, vitamin D deficiency was not associated with AD (p = 0.222).
Baseline vitamin D deficiency predicted the onset of NAD within 7 years among older women.
维生素 D 缺乏与痴呆和中风呈横断面相关。本纵向研究的目的是确定基线时血清维生素 D 缺乏是否可以预测 7 年内老年女性非阿尔茨海默病性痴呆（NAD）的发病。
来自 EPIDOS Toulouse 研究的 40 名高功能老年女性（78.4 岁，76.4/82.0；中位数，25 分位/75 分位）根据基线时的维生素 D 缺乏情况（即血清 25-羟维生素 D <10ng/ml）分为两组。在 7 年随访结束时，符合 DSM-IV 但不符合 NINCDS-ADRDA 标准的女性被诊断为 NAD，而符合 NINCDS-ADRDA 标准的女性被认为患有阿尔茨海默病（AD）。基线时的认知障碍轻微、心血管危险因素和帕金森病被用作潜在的混杂因素。
7 年后有 6 名女性（82.8 岁，80.6/86.0）报告 NAD。维生素 D 缺乏的女性 NAD 发生率更高（p=0.023）。两组 AD 发病情况无差异（p=0.332）。我们发现基线时维生素 D 缺乏与 NAD 的发病有关（调整后的优势比=19.57，p=0.042）。相反，维生素 D 缺乏与 AD 无关（p=0.222）。
基线时维生素 D 缺乏可预测老年女性 7 年内 NAD 的发病。
