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本文引用的文献

1
Waist Circumference, Body Mass Index, and Other Measures of Adiposity in Predicting Cardiovascular Disease Risk Factors among Peruvian Adults.腰围、体重指数及其他肥胖指标对秘鲁成年人心血管疾病风险因素的预测作用
Int J Hypertens. 2011 Jan 24;2011:931402. doi: 10.4061/2011/931402.
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[Waist-height ratio compared to other anthropometric indicators of obesity as predictors of high coronary risk].[与其他肥胖人体测量指标相比，腰高比作为高冠心病风险预测指标的研究]
Rev Assoc Med Bras (1992). 2009 Nov-Dec;55(6):705-11. doi: 10.1590/s0104-42302009000600015.
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Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: a meta-analysis.腹部肥胖指标在区分心血管危险因素方面比体重指数（BMI）更具优势：一项荟萃分析。
J Clin Epidemiol. 2008 Jul;61(7):646-53. doi: 10.1016/j.jclinepi.2007.08.012. Epub 2008 Mar 21.
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Impact of obesity on the risk for polycystic ovary syndrome.肥胖对多囊卵巢综合征风险的影响。
J Clin Endocrinol Metab. 2008 Jan;93(1):162-8. doi: 10.1210/jc.2007-1834. Epub 2007 Oct 9.
5
Evidence of subpopulations with different levels of insulin resistance in women with polycystic ovary syndrome.多囊卵巢综合征女性中存在不同胰岛素抵抗水平亚群的证据。
Hum Reprod. 2007 Nov;22(11):2974-80. doi: 10.1093/humrep/dem302. Epub 2007 Sep 25.
6
Accuracy of anthropometric indicators of obesity to predict cardiovascular risk.肥胖人体测量指标预测心血管风险的准确性。
J Clin Endocrinol Metab. 2007 Feb;92(2):589-94. doi: 10.1210/jc.2006-0254. Epub 2006 Nov 14.
7
Low testosterone and high C-reactive protein concentrations predict low hematocrit in type 2 diabetes.低睾酮和高C反应蛋白浓度可预测2型糖尿病患者的低血细胞比容。
Diabetes Care. 2006 Oct;29(10):2289-94. doi: 10.2337/dc06-0637.
8
Obesity and extreme obesity, manifest by ages 20-24 years, continuing through 32-41 years in women, should alert physicians to the diagnostic likelihood of polycystic ovary syndrome as a reversible underlying endocrinopathy.肥胖和极度肥胖在20至24岁时出现，在女性中持续至32至41岁，这应提醒医生多囊卵巢综合征作为一种可逆转的潜在内分泌病的诊断可能性。
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9
Which white blood cell subtypes predict increased cardiovascular risk?哪些白细胞亚型预示心血管风险增加？
J Am Coll Cardiol. 2005 May 17;45(10):1638-43. doi: 10.1016/j.jacc.2005.02.054. Epub 2005 Apr 25.
10
Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women's Health Initiative Observational Study.白细胞计数作为绝经后女性心血管事件和死亡率的预测指标：妇女健康倡议观察性研究
Arch Intern Med. 2005 Mar 14;165(5):500-8. doi: 10.1001/archinte.165.5.500.

保加利亚多囊卵巢综合征和/或肥胖患者的心血管危险因素

Cardiovascular Risk Factors in Bulgarian Patients with Polycystic Ovary Syndrome and/or Obesity.

作者信息

Gateva Antoaneta, Kamenov Zdravko

机构信息

Clinic of Endocrinology, University Hospital Alexandrovska, Medical University-Sofia, 1 Georgi Sofiiski Boulevard, 1431 Sofia, Bulgaria.

出版信息

Obstet Gynecol Int. 2012;2012:306347. doi: 10.1155/2012/306347. Epub 2012 Jan 4.

DOI:10.1155/2012/306347
PMID:22262974
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3259489/
Abstract

Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disturbances in women of reproductive age. Besides its well-known effects on reproductive health, it is also linked to increased cardiovascular risk in later life. The aim of this study is to investigate some classical cardiovascular risk factors in a crossectional study of Bulgarian women with PCOS and/or obesity. We performed a retrospective medical chart review of 375 women from an university endocrine clinic. We found significant differences in the indices of carbohydrate metabolism, blood pressure, lipid profile, rate of liver steatosis, and the levels liver enzymes and hematological results between the lean and obese PCOS women. Obese women without PCOS did not show significantly different results in their OGGT form obese PCOS women. Waist-to-stature-ratio (WSR) correlated better with the baseline IRI levels and lipid profile than waist-to-hip-ratio (WHR) that makes it a better marker for unfavorable metabolic profile.

摘要

多囊卵巢综合征（PCOS）是育龄女性中最常见的内分泌紊乱疾病之一。除了其对生殖健康的众所周知的影响外，它还与晚年心血管疾病风险增加有关。本研究的目的是在一项针对保加利亚患有PCOS和/或肥胖症的女性的横断面研究中，调查一些经典的心血管危险因素。我们对一所大学内分泌诊所的375名女性进行了回顾性病历审查。我们发现，瘦型和肥胖型PCOS女性在碳水化合物代谢指标、血压、血脂谱、肝脂肪变性率以及肝酶水平和血液学结果方面存在显著差异。无PCOS的肥胖女性在口服葡萄糖耐量试验（OGGT）中的结果与肥胖型PCOS女性无显著差异。腰高比（WSR）与基线胰岛素抵抗指数（IRI）水平和血脂谱的相关性比腰臀比（WHR）更好，这使其成为不良代谢状况的更好指标。