锌介导的溴代异戊烯基与亚胺的高 α-区域选择性烯丙基化反应。

Zinc-mediated highly α-regioselective prenylation of imines with prenyl bromide.

机构信息

School of Chemistry and Chemical Engineering, and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Xuzhou Normal University, Xuzhou 221116, Jiangsu, China.

出版信息

Org Lett. 2012 Feb 3;14(3):886-9. doi: 10.1021/ol203410m. Epub 2012 Jan 20.

DOI:10.1021/ol203410m

PMID:22263586

Abstract

A highly α-regioselective prenylation of imines has been successfully developed. The efficiency of this approach is confirmed by a wide range of imines including N- and C-aryl aldimines, N-alkyl aldimines, C-alkyl aldimines, and N- and C-aryl ketimines. The approach uses prenyl bromide as the prenyl source and inexpensive and convenient zinc as the mediator as well as environmentally benign 1,3-dimethyl-2-imidazolidinone (DMI) as the solvent.

摘要

一种高α-区域选择性的亚胺烯丙基化反应已被成功开发。该方法的效率通过广泛的亚胺包括 N-和 C-芳基亚胺、N-烷基亚胺、C-烷基亚胺和 N-和 C-芳基酮亚胺得到证实。该方法使用烯丙基溴作为烯丙基源，廉价且方便的锌作为介导物，以及环境友好的 1,3-二甲基-2-咪唑烷酮(DMI)作为溶剂。