Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Circuito Exterior, Coyoacan, C.P. 04510, Mexico D.F., Mexico.
Anticancer Agents Med Chem. 2012 Jul;12(6):611-8. doi: 10.2174/187152012800617713.
A series of 5-aryl-1,4-benzodiazepines with chloro- or fluoro-substituents in the second ring have been synthesized and their anti-inflammatory, myeloperoxidase and anticancer properties studied. The synthesized compounds showed potential anti-inflammatory and anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4- benzodiazepine.
一系列含有氯或氟取代基的 5-芳基-1,4-苯并二氮杂卓已被合成，并研究了它们的抗炎、髓过氧化物酶和抗癌特性。合成的化合物表现出潜在的抗炎和抗癌活性，而在 5-芳基-1,4-苯并二氮杂卓的第二个环中存在氯取代基时，其活性增强。
