Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.
J Int Neuropsychol Soc. 2012 May;18(3):606-11. doi: 10.1017/S1355617711001925. Epub 2012 Jan 23.
The purpose of this study was to investigate the relative effects of unilateral (left-sided) versus bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on verbal fluency. To do this, 10 Parkinson's disease patients with predominantly bilateral motor symptoms who received bilateral STN DBS were compared with 6 patients suffering from predominantly unilateral symptoms who received STN DBS on the left side only. The results suggest that unilateral STN DBS of the speech dominant hemisphere is associated with significantly less declines in measures of verbal fluency as compared to bilateral stimulation.
本研究旨在探讨单侧（左侧）与双侧丘脑底核（STN）深部脑刺激（DBS）对语言流畅性的相对影响。为此，我们比较了 10 例以双侧运动症状为主的接受双侧 STN-DBS 的帕金森病患者与 6 例仅接受左侧单侧症状 STN-DBS 的患者。结果表明，与双侧刺激相比，言语优势半球的单侧 STN-DBS 与语言流畅性测量值的下降显著减少相关。
