Department of Health Care, Bao'an Maternal and Child Health Hospital, Shenzhen, China.
Am J Obstet Gynecol. 2012 Mar;206(3):251.e1-7. doi: 10.1016/j.ajog.2011.12.021. Epub 2011 Dec 27.
To determine whether 5,10-methylenetetrahydrofolate reductase A1298C polymorphism is associated with neural tube defect susceptibility.
Computerized literature searches of the PubMed, Embase, and Medline database were conducted to identify all eligible articles. Study subjects were classified as neural tube defect patients, mothers with neural tube defect offspring and fathers with neural tube defect offspring. The pooled odds ratios with 95% confidence interval (CI) were calculated by fixed-effects model or random-effects model.
Twenty-three case-control studies were finally included. The pooled results showed no significant association between 5,10-methylenetetrahydrofolate reductase A1298C polymorphism and neural tube defect susceptibility in any genetic contrast among the 3 groups, except 1 (AC vs AA in neural tube defect patients: odds ratio, 1.16; 95% CI, 1.10-1.32; P = .03), which, however, turned out to be of no statistical significance in the subgroup of the white population (odds ratio, 1.14; 95% CI, 0.98-1.31; P = .08).
This metaanalysis suggests that 5,10-methylenetetrahydrofolate reductase A1298C polymorphism is not associated with neural tube defect susceptibility in the white population.
确定 5,10-亚甲基四氢叶酸还原酶 A1298C 多态性是否与神经管缺陷易感性相关。
计算机检索 PubMed、Embase 和 Medline 数据库，以确定所有合格的文章。研究对象分为神经管缺陷患者、有神经管缺陷后代的母亲和有神经管缺陷后代的父亲。采用固定效应模型或随机效应模型计算合并的优势比及其 95%置信区间（CI）。
最终纳入了 23 项病例对照研究。合并结果显示，在 3 组人群的任何遗传对照中，5,10-亚甲基四氢叶酸还原酶 A1298C 多态性与神经管缺陷易感性均无显著关联，除了 1 项（神经管缺陷患者中 AC 与 AA：优势比，1.16；95%CI，1.10-1.32；P =.03），但在白人亚组中无统计学意义（优势比，1.14；95%CI，0.98-1.31；P =.08）。
这项荟萃分析表明，5,10-亚甲基四氢叶酸还原酶 A1298C 多态性与白人的神经管缺陷易感性无关。
