de Charry F, de Charry C, Gérôme P, Pavic M, Lacoin Q, Pasquet F, Debourdeau P
Service de médecine interne oncologie, hôpital Desgenettes, 108 boulevard Pinel, Lyon, France.
Rev Med Interne. 2012 Mar;33(3):159-61. doi: 10.1016/j.revmed.2011.12.003. Epub 2012 Jan 20.
The sensitivity of the detection of irregular antibodies (DIA) is one of the fundamental basis of transfusion safety. The production of alloantibodies is the first cause of adverse events following transfusion.
We report a 77-year-old woman who was transfused and presented with a delayed haemolytic anemia due to anti-JK1 alloimmunization. This event highlights the limits of DIA performed before a transfusion, the hazard of this specific type of antibody and the difficulties of the diagnosis of haemolytic anaemia. The preventive measures necessary to avoid this undesirable effect are reminded.
Despite the sensitive routine test method, the anti-JK1 antibodies could be missed. We should keep in mind the possibility of an anaemia due to alloantibodies we confronted to an unexplained haemolytic episode.
不规则抗体检测（DIA）的敏感性是输血安全的基本依据之一。同种抗体的产生是输血后不良事件的首要原因。
我们报告一名77岁女性，她接受输血后因抗JK1同种免疫而出现迟发性溶血性贫血。这一事件凸显了输血前进行DIA的局限性、这种特定类型抗体的危险性以及溶血性贫血诊断的困难。文中还提醒了避免这种不良后果所需的预防措施。
尽管常规检测方法很灵敏，但抗JK1抗体仍可能漏检。当面对不明原因的溶血发作时，我们应牢记同种抗体导致贫血的可能性。
