University of Leicester, United Kingdom.
Int J Biochem Cell Biol. 2012 Apr;44(4):578-81. doi: 10.1016/j.biocel.2011.12.008. Epub 2012 Jan 13.
Eph receptors have been the subject of intense research since their discovery. Their widespread pattern of expression, involvement in a variety of important cellular phenomena and unique mode of action have stimulated interest in their role in health and disease across biological and medical domains. However, the function of Ephs in nervous system development and plasticity remains the best characterised. Recent advances suggest that Ephs play an important role in the development of brain pathologies. This review focuses on their basic structure and function and discusses the latest research on their role in neurological diseases.
Eph 受体自发现以来一直是研究的热点。它们广泛的表达模式、参与多种重要的细胞现象以及独特的作用方式，激发了人们对它们在生物和医学领域的健康和疾病中的作用的兴趣。然而，Eph 在神经系统发育和可塑性中的功能仍然是最具特征的。最近的进展表明，Eph 在脑病理学的发展中发挥着重要作用。本文综述了它们的基本结构和功能，并讨论了它们在神经疾病中的最新研究进展。
