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启动胰高血糖素样肽-1受体激动剂用于2型糖尿病的管理。

Initiating a glucagon-like peptide-1 receptor agonist in the management of type 2 diabetes mellitus.

作者信息

Gavin James R

机构信息

Healing Our Village, Inc, Lanham, Maryland, USA.

出版信息

J Am Osteopath Assoc. 2012 Jan;112(1 Suppl 1):S16-21.

PMID:22267299
Abstract

Control of blood glucose levels and restoration of pancreatic islet function are among the goals of physicians seeking to improve outcomes in patients with type 2 diabetes mellitus (T2DM). A growing body of evidence supports the use of incretins to achieve these goals, and current guidelines recommend earlier and more frequent use of these agents. However, in patients with T2DM, treatment paradigms should always be individualized. The author discusses issues for physicians to consider when adjusting T2DM therapy, including patient comorbidities, glucose control patterns, and potential adverse effects. The importance of patient education and practical points for initiating a glucagon-like peptide-1 receptor agonist are also reviewed.

摘要

控制血糖水平和恢复胰岛功能是寻求改善2型糖尿病(T2DM)患者治疗效果的医生的目标之一。越来越多的证据支持使用肠促胰岛素来实现这些目标,当前指南建议更早、更频繁地使用这些药物。然而,对于T2DM患者,治疗方案应始终个体化。作者讨论了医生在调整T2DM治疗时应考虑的问题,包括患者的合并症、血糖控制模式和潜在的不良反应。还回顾了患者教育的重要性以及启动胰高血糖素样肽-1受体激动剂的实用要点。

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1
Initiating a glucagon-like peptide-1 receptor agonist in the management of type 2 diabetes mellitus.启动胰高血糖素样肽-1受体激动剂用于2型糖尿病的管理。
J Am Osteopath Assoc. 2012 Jan;112(1 Suppl 1):S16-21.
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Incorporating glucagon-like peptide-1 receptor agonists into clinical practice.将胰高血糖素样肽-1受体激动剂纳入临床实践。
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Physiologic and weight-focused treatment strategies for managing type 2 diabetes mellitus: the metformin, glucagon-like peptide-1 receptor agonist, and insulin (MGI) approach.以生理和体重为中心的 2 型糖尿病治疗策略:二甲双胍、胰高血糖素样肽-1 受体激动剂和胰岛素(MGI)方法。
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Improving glucagon-like peptide-1 dynamics in patients with type 2 diabetes mellitus.改善2型糖尿病患者胰高血糖素样肽-1的动态变化
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Does glucagon-like peptide-1 receptor agonist therapy add value in the treatment of type 2 diabetes? Focus on exenatide.胰高血糖素样肽-1 受体激动剂治疗在 2 型糖尿病治疗中是否具有价值?以艾塞那肽为例。
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[Beyond glycemic control in type 2 diabetes. Promises and gambles of therapy with glucagon-like peptide-1 receptor agonists].[2型糖尿病的血糖控制之外。胰高血糖素样肽-1受体激动剂治疗的前景与风险]
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Partnering with patients to improve therapeutic outcomes: incretin-based therapy for type 2 diabetes.与患者合作改善治疗效果:基于肠促胰岛素的 2 型糖尿病治疗。
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Practical applications of therapy with a glucagon-like peptide-1 receptor agonist.胰高血糖素样肽-1受体激动剂治疗的实际应用。
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Advances in the treatment of type 2 diabetes mellitus.2 型糖尿病治疗进展。
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引用本文的文献

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Glucagon-like peptide-1 potentiates glucose-stimulated insulin secretion via the transient receptor potential melastatin 2 channel.胰高血糖素样肽-1通过瞬时受体电位香草酸亚型2通道增强葡萄糖刺激的胰岛素分泌。
Exp Ther Med. 2017 Nov;14(5):5219-5227. doi: 10.3892/etm.2017.5136. Epub 2017 Sep 19.
2
Enhanced Incretin Effects of Exendin-4 Expressing Chimeric Plasmid Based On Two-Step Transcription Amplification System with Dendritic Bioreducible Polymer for the Treatment of Type 2 Diabetes.基于具有树枝状生物可还原聚合物的两步转录扩增系统的艾塞那肽-4表达嵌合质粒增强肠促胰岛素效应用于2型糖尿病的治疗
J Gene Ther. 2013 Dec 1;1(1):7-15.