Hassan I B, Hagberg H, Sundström C
Department of Pathology, University Hospital, Uppsala, Sweden.
Eur J Haematol. 1990 Sep;45(3):172-6. doi: 10.1111/j.1600-0609.1990.tb00447.x.
15 cases of HCL were studied with a panel of monoclonal antibodies against different leukocyte antigens. A B-cell phenotype different from that of B-CLL was observed (CD10-, CD19+, CD20+, CD21-, CD22+, CD37+, CD38-, FMC7+, LN1+, PCA-1+, BLy7+ and CD5-). As expected, CD11c and CD25 were positive and, in addition, a My7 and My9 positivity in varying degree was noted. 3 weeks of in vitro incubation did not significantly alter the phenotype. We conclude that HCL exhibits a unique phenotype among chronic B-cell leukemias, which is closer to the plasma cell stage of differentiation than that of B-CLL. The BLy7 monoclonal antibody seems to be a promising marker for HCL.
应用一组抗不同白细胞抗原的单克隆抗体对15例毛细胞白血病（HCL）进行了研究。观察到一种不同于B细胞慢性淋巴细胞白血病（B-CLL）的B细胞表型（CD10阴性、CD19阳性、CD20阳性、CD21阴性、CD22阳性、CD37阳性、CD38阴性、FMC7阳性、LN1阳性、PCA-1阳性、BLy7阳性及CD5阴性）。正如所预期的，CD11c和CD25呈阳性，此外，还注意到My7和My9呈不同程度的阳性。体外培养3周并未显著改变该表型。我们得出结论，HCL在慢性B细胞白血病中表现出独特的表型，与B-CLL相比，它更接近浆细胞分化阶段。BLy7单克隆抗体似乎是HCL的一个有前景的标志物。
