Wuxi Maternity and Child Health Hospital Affiliated Nanjing Medical University, China.
Reprod Sci. 2012 May;19(5):534-8. doi: 10.1177/1933719111426605. Epub 2012 Jan 19.
This was a retrospective study of the effectiveness of trichosanthin (TCS), an active component isolated from the Chinese herb root tuber of Trichosanthes kirilowii on 140 cases of ectopic pregnancy with higher levels of β-human chorionic gonadotropin (β-hCG) managed with a single dose of TCS treatment. Trichosanthin has been used for medical treatment of ectopic pregnancy in China since the 1980s. This study was performed in a major teaching hospitals in China. The mean pretreatment level of β-hCG in the TCS treatment group was 3387.57 IU/L. The success rate of TCS treatment was 85% (119 of 140) which was similar to methotrexate (MTX) treatment. In 86 women with a high level of β-hCG (over 2000 IU/L), the success rate was 80.08% when treated with TCS. Of this group, 26 women who had a high level of β-hCG (over 5000 IU/L) showed a success rate of 73%. The level of β-hCG on days 4, 7, and 10 in TCS group was significantly decreased. This study has shown that TCS may be an option for the medical treatment of unruptured ectopic pregnancy or an option for the treatment of ectopic pregnancy with higher levels of β-hCG than currently recommended for medical management with MTX.
这是一项回顾性研究，评估了从中药天花粉中提取的有效成分天花粉蛋白（TCS）对 140 例β-人绒毛膜促性腺激素（β-hCG）水平较高的异位妊娠单次 TCS 治疗的疗效。自 20 世纪 80 年代以来，中国一直将天花粉蛋白用于异位妊娠的治疗。本研究在中国一家大型教学医院进行。TCS 治疗组治疗前的平均β-hCG 水平为 3387.57IU/L。TCS 治疗的成功率为 85%（119/140），与甲氨蝶呤（MTX）治疗相似。在 86 例β-hCG 水平较高（超过 2000IU/L）的妇女中，TCS 治疗的成功率为 80.08%。其中，26 例β-hCG 水平较高（超过 5000IU/L）的妇女成功率为 73%。TCS 组第 4、7、10 天的β-hCG 水平明显下降。本研究表明，TCS 可能是未破裂型异位妊娠的治疗选择，也可能是目前推荐使用 MTX 进行药物治疗的β-hCG 水平较高的异位妊娠的治疗选择。
