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[对去氢甲睾酮在白鼠体内代谢产物结构的分析]

[An analysis of the structure of the metabolic products of methandrostenolone in the body of white rats].

作者信息

Krynetskiĭ E Iu, Maruzhenkov D S, ProKhorov B S, Rylin A F

出版信息

Farmakol Toksikol. 1990 Jul-Aug;53(4):51-3.

PMID:2226762
Abstract

The products of biotransformation of an anabolic steroidal drug methandrostenolone in the Wistar albino rat organism were studied. By using the developed methods of HPLC the products of a complete reduction of methandrostenolone were isolated and their chemical structures were determined. It was found that at the reduction of the system of methandrostenolone double bonds were formed all four possible isomers.

摘要

对合成代谢甾体药物美雄酮在Wistar白化大鼠机体中的生物转化产物进行了研究。通过使用所开发的高效液相色谱法,分离出了美雄酮完全还原的产物,并确定了它们的化学结构。结果发现,在美雄酮双键还原体系中形成了所有四种可能的异构体。

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