人精子顶体蛋白酶-胰蛋白酶抑制剂（HUSI-II）的氨基酸序列解析表明，卡扎尔型蛋白酶抑制剂在结构上与糖蛋白激素的β亚基相关。
Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to beta-subunits of glycoprotein hormones.
作者信息
Fink E, Hehlein-Fink C, Eulitz M
机构信息
Department of Clinical Chemistry and Clinical Biochemistry, University of Munich, FRG.
出版信息
FEBS Lett. 1990 Sep 17;270(1-2):222-4. doi: 10.1016/0014-5793(90)81273-q.
PMID:2226783
Abstract
The amino acid sequence of the acrosin-trypsin inhibitor HUSI-II from human seminal plasma is presented which unequivocally identifies HUSI-II as being of Kazal-type. In addition, the HUSI-II sequence shows a striking similarity to the middle part of glycoprotein hormone beta-subunits thus revealing a hitherto unknown structural and evolutionary relationship between Kazal-type inhibitors and glycoprotein hormones.
摘要
本文给出了人精浆中顶体蛋白酶-胰蛋白酶抑制剂HUSI-II的氨基酸序列，该序列明确鉴定HUSI-II为卡扎尔型。此外，HUSI-II序列与糖蛋白激素β亚基的中部具有显著相似性，从而揭示了卡扎尔型抑制剂与糖蛋白激素之间迄今未知的结构和进化关系。
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