Llorente-González Sara, Peralta-Calvo J, Abelairas-Gómez J M
Ophthalmology Service of Hospital de Torrejón, Madrid, Spain.
Clin Ophthalmol. 2011;5:1759-65. doi: 10.2147/OPTH.S27189. Epub 2011 Dec 13.
To describe the prevalence of congenital anophthalmia and microphthalmia in Hospital Universitario La Paz, and to identify associated risk factors and evaluate cosmetic results in treated and nontreated patients.
A retrospective, descriptive, cross-sectional study of patients treated with orbital expanding techniques (cases) and nontreated patients (controls) was carried out as a comparative case series study. A total of 36 patients with unilateral or bilateral anophthalmia or microphthalmia as main diagnosis were included; 52 epidemiological and management variables for each patient were analyzed. The study evaluated orbital growth and facial symmetry.
The overall cosmetic result in the study's group of patients was satisfactory: 66.7% showed good or very good orbital growth, and 75% showed good or very good facial symmetry. Controls had better cosmetic outcome but showed more cataracts (P = 0.05), inferior colobomas (P = 0.026), and family history (P = 0.056) than the cases. Controls also showed significantly better orbital growth (P = 0.042) and facial symmetry (P = 0.014) than the cases.
This study suggests that the mere presence of a globe (controls) still provides better orbitofacial development than the artificial stimulation (cases) currently available for patients with congenital anophthalmia and microphthalmia, who receive internal and external orbital rehabilitation.
描述拉巴斯大学医院先天性无眼球和小眼球的患病率,确定相关危险因素,并评估接受治疗和未接受治疗患者的美容效果。
作为一项比较病例系列研究,对采用眼眶扩张技术治疗的患者(病例组)和未接受治疗的患者(对照组)进行了一项回顾性、描述性横断面研究。共纳入36例以单侧或双侧无眼球或小眼球为主要诊断的患者;分析了每位患者的52个流行病学和管理变量。该研究评估了眼眶生长和面部对称性。
研究组患者的总体美容效果令人满意:66.7%的患者眼眶生长良好或非常好,75%的患者面部对称性良好或非常好。对照组的美容效果更好,但白内障(P = 0.05)、下方缺损(P = 0.026)和家族史(P = 0.056)的发生率高于病例组。对照组的眼眶生长(P = 0.042)和面部对称性(P = 0.014)也明显优于病例组。
本研究表明,对于接受内外眼眶修复的先天性无眼球和小眼球患者,仅仅有眼球(对照组)仍比目前可用的人工刺激(病例组)提供更好的眶面部发育。