Angenon G, Van Montagu M, Depicker A
Laboratorium voor Genetica, Rijksuniversiteit Gent, Belgium.
FEBS Lett. 1990 Oct 1;271(1-2):144-6. doi: 10.1016/0014-5793(90)80392-v.
A region of 18 nucleotides surrounding the stop codon (the stop codon context) in 748 plant nuclear genes was analyzed. Non-randomness was found both upstream and downstream from the stop codon, suggesting that these sequences may help in ensuring efficient termination of translation. The UAG amber codon is the least-used stop codon and the bias in the nucleotide distribution 5' and 3' to the stop codon was more pronounced for the amber codon than for the other stop codons. This might indicate that the codon context affects termination more at UAG than at UGA or UAA stop codons.
对748个植物核基因中围绕终止密码子的18个核苷酸区域（终止密码子上下文）进行了分析。在终止密码子的上游和下游均发现了非随机性，这表明这些序列可能有助于确保翻译的有效终止。UAG琥珀密码子是使用最少的终止密码子，并且相对于其他终止密码子，终止密码子5'和3'端的核苷酸分布偏向于琥珀密码子更为明显。这可能表明密码子上下文对UAG处终止的影响比对UGA或UAA终止密码子处的影响更大。
