Department of Pathology, Haartman Institute, University of Helsinki and HUSLAB, Helsinki, Finland.
J Clin Pathol. 2012 Apr;65(4):333-8. doi: 10.1136/jclinpath-2011-200402. Epub 2012 Jan 21.
Well-differentiated follicular thyroid carcinoma usually has a favourable prognosis and metastases are rare. Toll-like receptors (TLRs) that take part in adaptive and innate immunity have, in many tumours, both apoptotic and antiapoptotic effects, making their role in tumourigenesis controversial. Chronic inflammation is involved in many cancers.
To examine the clinical relevance of TLR-2, TLR-4, and CD45 in follicular thyroid neoplasias.
The authors studied the immunohistochemical expression of TLR-2 and TLR-4 in 127 follicular thyroid neoplasms, both in adenomas and in carcinomas including oxyphilic tumours. Their degree of chronic inflammation was evaluated by a count of CD45-positive lymphocytes within and adjacent to the tumourous tissue.
Both high TLR-4 expression and lack of TLR-4 expression in carcinomas were associated with metastatic and aggressive disease. In oxyphilic tumours, both in adenomas and in carcinomas, TLR-4 expression was significantly stronger. TLR-2 expression was stronger in adenomas than in carcinomas but without any correlation with clinical variables. Degree of chronic inflammation outside the primary tumour was lower for metastasized carcinomas than for non-metastasised carcinomas.
Varying expression of TLR-4 and lack of inflammation are indicators of aggressive disease among follicular thyroid cancer.
分化良好的滤泡状甲状腺癌通常预后良好，转移少见。在许多肿瘤中，参与适应性和先天性免疫的 Toll 样受体（TLRs）具有凋亡和抗凋亡作用，这使得它们在肿瘤发生中的作用存在争议。慢性炎症与许多癌症有关。
研究 TLR-2、TLR-4 和 CD45 在滤泡性甲状腺肿瘤中的临床相关性。
作者研究了 TLR-2 和 TLR-4 在 127 例滤泡性甲状腺肿瘤中的免疫组织化学表达，包括腺瘤和癌，包括嗜酸细胞肿瘤。通过对肿瘤组织内和周围的 CD45 阳性淋巴细胞进行计数来评估其慢性炎症程度。
癌组织中 TLR-4 的高表达和缺乏 TLR-4 表达均与转移和侵袭性疾病相关。在嗜酸细胞肿瘤中，无论是腺瘤还是癌，TLR-4 的表达均明显增强。TLR-2 的表达在腺瘤中强于癌，但与临床变量无关。与未转移的癌相比，转移的癌的肿瘤外慢性炎症程度较低。
滤泡状甲状腺癌中 TLR-4 的表达变化和缺乏炎症是侵袭性疾病的指标。
